Monday the 6th September.
Session 1: Virulence and Pathogenesis. Chaired by Vance Fowler.
09.00- 09.15: Welcome + safety notices.
09.15- 09.45: Jerome Etienne. "The virulence of PVL-positive S. aureus regardless of methicillin-resistance"
09.45- 10.15: Julie Wardenburg. “Staphylococcus aureus infection: new insights on alpha-hemolysin mediated injury.”
10.15- 10.30: Proffered paper: Sinead McNicholas. “The contribution of bacterial virulence and the host immune response to the clinical course of Staphylococcus aureus bloodstream infection.”
10.30- 11.00: Coffee.
11.00- 11.30: Ben Howden. "Molecular mechanisms and approaches to laboratory detection of hVISA".
11.30- 11.45: Proffered paper: Gillian J. Wilson. “Discovery and characterization of a Staphylococcus aureus core genome-encoded superantigen.”
11.45- 12.00: Proffered paper: Andrew Edwards. “Escape from the bloodstream: the role of the multiple binding repeats of FnBPA.”
12.00- 14.00: Lunch and poster viewing
Session 2: Staphylococcal Persistence. Chaired by Ruth Massey.
14.00- 14.30: Alexander Tomasz. “Evolution of staphylococcal antibiotic resistance in vivo.”
14.30- 15.00: Barbara Kahl. “Mutations of thymidylate synthase (thyA) as a patho-adaptive mechanism of Staphylococcus aureus in the airways of cystic fibrosis patients.”
15.00- 15.15: Proffered paper: Paul McAdam. “Genome scale analysis of the microevolution of Staphylococcus aureus during chronic infection of the cystic fibrosis lung.”
15.15- 15.45: Coffee
15.45- 16.15: Ken Bayles. "Staphylococcal biofilm development: a life or death situation."
16.15- 16.45: Jim O'Gara. “Novel roles for the major autolysin and the fibronectin binding proteins in promoting MRSA biofilm development “
16.45- 17.00: Proffered paper: Emma Budd. “Evolution of antibiotic resistance in clinical MRSA.”
17.00-19.00 Welcome Reception
Tuesday the 7th September.
Session 3: Other Staphylococci. Chaired by Ross Fitzgerald.
09.00-09.30: Steve Gill. “Commensals and Pathogens: an enterotoxin-bearing pathogenicity island in Staphylococcus epidermidis (SePI) and genomes of Staphylococcus lugdunensis. “
09.30-10.00: Dietrich Mack. “Mechanisms of Staphylococcus epidermidis biofilm formation.”
10.00-10.15: Proffered paper: Steven Tong. “Genome sequence of an ancestral Staphylococcus aureus. “
10.15-10.45: Coffee.
10.45-11.15: Soeren Gatermann. “Staphylococcus saprophyticus – clinical presentations and virulence factors. “
11.15- 11.30: Proffered paper: Michael Otto. “Staphylococcus epidermidis strategies to avoid killing by human neutrophils.
11.30- 12.00: Joseph John. “The increasing clinical relevance of the “other” staphylococci.”
12.00-14.30: Lunch and poster viewing.
12.30-14.00: bioMérieux sponsored lunchtime symposium "PVL Associated Infections: an overview”.
Session 4: Sensing and Regulation. Chaired by Mal Horsburgh.
14.30- 15.00: Susanne Engelmann. “Physiological proteome analyses in Staphylococcus aureus: From stimulons to regulons to adaptational regulatory networks.”
15.00- 15.30: Dominique Missiakas. “Establishment of abscess lesions: Contribution of the ESAT-6 secretion system.”
15.30- 15.45: Proffered paper: Marc Burian. “In vivo Genexpression Analysis of Staphylococcus aureus during Host-Microbe Interaction and the Regulatory Adaptation to the Human Nose.”
15.45- 16.15: Coffee
16.15-16.45: Ambrose Cheung. “The MazEF system of S. aureus and the role of DEAD-box proteins in preventing mRNA cleavage by the toxin MazF.”
16.45- 17.15: Alexander Horswill. “Staphylococcus aureus nuclease: new insights on an old enzyme”
17.15- 17.30: Proffered paper: Tarek Msadek. “The WalKR (YycGF) Essential Signal Transduction Pathway and Pathogenesis of Staphylococcus aureus.”
18.30- 0nwards: Curry Night at the Eastern Eye Restaurant.
Wednesday the 8th of September
Session 5: Disease Management. Chaired by Sharon Peacock and Graeme Nimmo.
09.00- 09.30: Vance Fowler. "Recent challenges and advances in antimicrobial therapy".
09.30- 10.00: Marc Bonten. "Controlling MRSA in hospitals: which interventions work?"
10.00-10.15: Proffered paper: Natasha Holmes. “Increased mortality in patients with Staphylococcus aureus bacteraemia (SAB) with elevated vancomycin MIC regardless of antibiotic treatment.”
10.15-10.30: Proffered paper: M.G. Schmidt. “Risk assessment and mitigation of the clinical environment: reducing the microbial burden through the introduction of antimicrobial copper objects.”
10.30-11.00: Coffee.
11.00-11.30: Stephan Harbarth. "Controlling MRSA in the community: can it work? "
11.30- 11.45: Proffered paper: Ben Cooper. “Estimating the ward-level reproduction numbers of different clonal subgroups of methicillin-resistant S. aureus in the intensive care unit.”
11.45-12.00: Proffered paper: Kyra Chua. “Understanding Increased Virulence of ST93-MRSA-IV, a Unique Australian Clone of Community Methicillin-Resistant Staphylococcus aureus.”
12.00- 14.30: Lunch and poster viewing.
12.30- 14.00: Alere and Pfizer Animal Health sponsored lunchtime session on “Animal Staphylococci.”
Session 5: Immune Evasion. Chaired by Tim Foster and Jean van den Elsen.
14.30-15.00: Jos van Strijp. “Staphylococcal Immune Evasion.”
5.00- 15.30: Victor Nizet. “Bacteria that frustrate the phagocyte”
15.30- 15.45: Proffered paper: Kenji Cunnion. “Complement regulator factor I interacts with clumping factor A (ClfA) on the Staphylococcus aureus surface to cleave C3b and inhibit complement-mediated phagocytosis.”
15.45-16.00: Proffered paper: Emma Jane Smith. “Sbi is an immune evasion protein.”
16.00- 16.30: Coffee
16.30- 17.00: Brian Geisbrecht. “Allosteric Inhibition of Complement Function by a Staphylococcal Immune Evasion Protein.”
17.00- 17.15: Proffered paper: Carla de Haas. “Structural basis for inhibition of FcγRIIA by FLIPr-like.”
17.15- 17.30: Proffered paper: Ya Ping Ko. “Staphylococcus aureus extracellular fibrinogen binding protein inhibits neutrophil phagocytosis and modulates innate immunity by blocking neutrophil-fibrinogen interactions.”
19.30- onwards: Symposium Dinner at the Roman Baths and Pump Room.
Thursday the 9th September.
Session 7: Population Structure and Evolution. Chaired by Ed Feil and Mark Enright.
09.00- 09.30: Ashley Robinson. “Targets of positive natural selection in staphylococci”
09.30- 10.00: Stephen Bentley. “Viewing the evolution of MRSA through whole genome sequences.”
10.00-10.15: Proferred paper: Stephen Ritchie. “The population structure of Staphylococcus aureus causing infection in New Zealand and Pacific Island nations.”
10.15-10.45: Coffee.
10.45-11.15: Maria Miragaia. “Staphylococcus epidermidis: strategies of adaptation to hospital and community environments.”
11.15- 11.45: Mark Enright. “S. aureus lytic phage: host range and bacterial population structure.”
11.45-12.00: Proffered paper: Anna Shore. “Identification and Molecular Characterisation of ACME among ST22-MRSA-IV Isolates.”
12.00: Conference end.